23 Augustus 2025
| 18:30 |
Genoa CFC 
0 - 0
US Lecce 
|
29 Augustus 2025
| 20:45 |
US Lecce
0 - 2
AC Milan 
|
14 September 2025
| 15:00 |
Atalanta BC 
4 - 1
US Lecce
|
19 September 2025
| 20:45 |
US Lecce
1 - 2
Cagliari Calcio 
|
28 September 2025
| 18:00 |
US Lecce
2 - 2
Bologna FC 1909 
|
04 Oktober 2025
| 15:00 |
Parma Calcio 1913 
0 - 1
US Lecce
|
18 Oktober 2025
| 15:00 |
US Lecce
0 - 0
US Sassuolo Calcio 
|
25 Oktober 2025
| 15:00 |
Udinese Calcio 
3 - 2
US Lecce
|
28 Oktober 2025
| 18:30 |
US Lecce
0 - 1
SSC Napoli 
|
02 November 2025
| 15:00 |
ACF Fiorentina 
0 - 1
US Lecce
|
08 November 2025
| 15:00 |
US Lecce
0 - 0
Hellas Verona FC 
|
23 November 2025
| 18:00 |
SS Lazio 
2 - 0
US Lecce
|
30 November 2025
| 12:30 |
US Lecce
2 - 1
Torino FC 
|
07 December 2025
| 12:30 |
US Cremonese 
2 - 0
US Lecce
|
12 December 2025
| 20:45 |
US Lecce
1 - 0
Pisa SC 
|