06 Juli 2025
| 23:00 |
Seattle Sounders FC 
0 - 1
Columbus Crew 
|
13 Juli 2025
| 02:36 |
FC Cincinnati 
2 - 4
Columbus Crew
|
17 Juli 2025
| 02:30 |
Nashville SC 
3 - 0
Columbus Crew
|
20 Juli 2025
| 02:15 |
Columbus Crew
2 - 1
D.C. United SC 
|
26 Juli 2025
| 02:40 |
Columbus Crew
1 - 3
Orlando City SC 
|
17 Augustus 2025
| 01:30 |
Toronto FC 
1 - 1
Columbus Crew
|
24 Augustus 2025
| 01:30 |
Columbus Crew
1 - 2
New England Revolution 
|
31 Augustus 2025
| 01:30 |
New York Red Bulls 
0 - 0
Columbus Crew
|
14 September 2025
| 01:30 |
Atlanta United FC 
4 - 5
Columbus Crew
|