17 Augustus 2024
| 16:00 |
Newcastle United FC 
1 - 0
Southampton FC 
|
24 Augustus 2024
| 16:00 |
Southampton FC
0 - 1
Nottingham Forest FC 
|
31 Augustus 2024
| 16:00 |
Brentford FC 
3 - 1
Southampton FC
|
14 September 2024
| 13:30 |
Southampton FC
0 - 3
Manchester United FC 
|
21 September 2024
| 16:00 |
Southampton FC
1 - 1
Ipswich Town FC 
|
30 September 2024
| 21:00 |
AFC Bournemouth 
3 - 1
Southampton FC
|
05 Oktober 2024
| 16:00 |
Arsenal FC 
3 - 1
Southampton FC
|
19 Oktober 2024
| 16:00 |
Southampton FC
2 - 3
Leicester City FC 
|
26 Oktober 2024
| 16:00 |
Manchester City FC 
1 - 0
Southampton FC
|
02 November 2024
| 16:00 |
Southampton FC
1 - 0
Everton FC 
|
09 November 2024
| 16:00 |
Wolverhampton Wanderers FC 
2 - 0
Southampton FC
|
24 November 2024
| 15:00 |
Southampton FC
2 - 3
Liverpool FC 
|
29 November 2024
| 21:00 |
Brighton & Hove Albion FC 
1 - 1
Southampton FC
|
04 December 2024
| 20:30 |
Southampton FC
1 - 5
Chelsea FC 
|
07 December 2024
| 16:00 |
Aston Villa FC 
1 - 0
Southampton FC
|
15 December 2024
| 20:00 |
Southampton FC
0 - 5
Tottenham Hotspur FC 
|
22 December 2024
| 15:00 |
Fulham FC 
0 - 0
Southampton FC
|
26 December 2024
| 16:00 |
Southampton FC
0 - 1
West Ham United FC 
|
29 December 2024
| 16:00 |
Crystal Palace FC 
2 - 1
Southampton FC
|
04 Januari 2025
| 16:00 |
Southampton FC
0 - 5
Brentford FC
|
12 Januari 2025
| 17:30 |
Southampton FC
3 - 0
Swansea City AFC 
|
16 Januari 2025
| 21:00 |
Manchester United FC
3 - 1
Southampton FC
|
19 Januari 2025
| 15:00 |
Nottingham Forest FC
3 - 2
Southampton FC
|
25 Januari 2025
| 16:00 |
Southampton FC
1 - 3
Newcastle United FC
|
01 Februari 2025
| 16:00 |
Ipswich Town FC
1 - 2
Southampton FC
|
08 Februari 2025
| 16:00 |
Southampton FC
0 - 1
Burnley FC 
|
15 Februari 2025
| 16:00 |
Southampton FC
1 - 3
AFC Bournemouth
|
22 Februari 2025
| 16:00 |
Southampton FC
0 - 4
Brighton & Hove Albion FC
|
25 Februari 2025
| 21:15 |
Chelsea FC
4 - 0
Southampton FC
|
08 Maart 2025
| 16:00 |
Liverpool FC
3 - 1
Southampton FC
|
15 Maart 2025
| 16:00 |
Southampton FC
1 - 2
Wolverhampton Wanderers FC
|
02 April 2025
| 20:45 |
Southampton FC
1 - 1
Crystal Palace FC
|
06 April 2025
| 15:00 |
Tottenham Hotspur FC
3 - 1
Southampton FC
|
12 April 2025
| 16:00 |
Southampton FC
0 - 3
Aston Villa FC
|
19 April 2025
| 16:00 |
West Ham United FC
1 - 1
Southampton FC
|
26 April 2025
| 16:00 |
Southampton FC
1 - 2
Fulham FC
|
03 Mei 2025
| 16:00 |
Leicester City FC
2 - 0
Southampton FC
|
10 Mei 2025
| 16:00 |
Southampton FC
0 - 0
Manchester City FC
|
18 Mei 2025
| 13:00 |
Everton FC
2 - 0
Southampton FC
|
25 Mei 2025
| 17:00 |
Southampton FC
1 - 2
Arsenal FC
|