10 Augustus 2025
| 18:00 |
FC Famalicão 
3 - 0
CD Santa Clara 
|
17 Augustus 2025
| 19:00 |
CD Santa Clara
0 - 1
Moreirense FC 
|
31 Augustus 2025
| 21:30 |
CD Santa Clara
0 - 0
CF Estrela da Amadora 
|
06 September 2025
| 21:30 |
Estoril Praia 
0 - 1
CD Santa Clara
|
12 September 2025
| 21:15 |
Sport Lisboa e Benfica 
1 - 1
CD Santa Clara
|
20 September 2025
| 16:30 |
CD Santa Clara
2 - 1
FC Alverca 
|
27 September 2025
| 17:30 |
CD Santa Clara
1 - 2
CD Tondela 
|
04 Oktober 2025
| 21:30 |
Vitória SC 
2 - 1
CD Santa Clara
|
25 Oktober 2025
| 19:00 |
CD Santa Clara
2 - 0
AVS Futebol 
|